My dog (12 year old toy poodle, suffers from nerve disorder, athritis, and a few other minor age-related ailments) had an immediate adverse reaction to this tincture. His blood pressure (no history of hypertension or hypotension) dropped, he began vomiting and was rather disoriented and quite shaky. Tail still wagging, mind you. He's not a large d g by any means, so even though this particular dose was made for smaller breeds, I only administered half the dosage recommendation with safety in mind. Not quite the review-worthy experience, but with a dog's health in mind, I found it necessary to say something in case someone else may find themselves in a similar difficult situation.